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Subgroup analysis showed significant differences of the lnDOR between six different populations of participants. Blockade of the portal system reduces the secretion of LH and FSH and leads to ovarian atrophy and a reduction in ovarian hormone secre- Hypothalamus tion. Disuse atrophy is a local at- dation for subsequent diagnosis, prognosis, treatment, and rophy that results from the inactivity of a tissue or organ. Many NSAIDs, but particularly indometacin, cause lithium retention by reducing its excretion by the kidneys.
Thus indometacin users have an elevated risk of lithium toxicity.
For patients taking lithium e. All NSAIDs, including indometacin, also increase plasma renin activity and aldosterone levels, and increase sodium and potassium retention. Vasopressin activity is also enhanced. Together these may lead to: These conditions also often begin with edema and hyperkalemia.
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There are unsubstantiated reports of worsening Parkinson’s disease, epilepsy, and psychiatric disorders. Cases of life-threatening shock including angioedema, sweating, severe hypotension and coachplusplus.ch as well as acute bronchospasm, severe or lethal hepatitis and severe bone marrow damage have all been reported. Skin reactions and photosensitivity are generic Indocin 50 mg United States possible side effects. Its use in acute gout attacks and in dysmenorrhea is well-established because in these indications the duration of treatment is limited to a few days only, therefore serious side effects are not likely to occur.